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NFL Prop Bets: Los Angeles Rams vs San Francisco 49ers - Week 1

The San Francisco 49ers (0-0) face the Los Angeles Rams (0-0) at MCG for Week 1. Let's take a look at the NFL Prop Bets for Friday's matchup. The Rams started the week as 2.5-point favorites but the spread has since moved to 3.0, leaving the Rams at -177 and 49ers at +145.

The total points line is set at 48.5, with OVER at -110 and UNDER at -110, meaning the implied expected score for the game is 26-23 LA Rams.

  • The 49ers (+100) had a 10-7-2 ATS record last season, while the Rams (-121) held a record of 12-8-0.
  • The 49ers had an 11-7-1 O/U record last season (meaning 11 games went over the total points line, seven went under and one resulted in a push). The Rams had a 12-8-0 O/U record last season.

Points on the board

  • The 49ers scored 25.7 points per game last season (10th in the league). Comparatively, the Rams averaged 30.5 (1st).
  • Defensively, the 49ers conceded 21.8 points per game last season (13th in the league), while the Rams gave up an average of 20.4 points (10th).

Moving the chains

  • With an average of 351.4, the 49ers ranked 7th in the league for total yards per game last season. Comparatively, the Rams ranked 1st with 394.6 yards per game.
  • In terms of yards allowed, the 49ers gave up 340.2 per game last season (20th in the league), while the Rams have allowed an average of 327.5 (17th).

Ascendency in the air

  • The 49ers averaged 244.5 passing yards per game last season (5th in the league). Comparatively, the Rams' defense gave up 216.7 passing yards per game (19th) last season.
  • Meanwhile, the Rams averaged 268.1 passing yards per game last season (1st in the league), while the 49ers' defense gave up 232.4 passing yards per game (25th) during the 2025 season.

Advantage on the ground

  • Looking at the ground game, the 49ers averaged 106.9 rushing yards per game last season (24th in the league). Conversely, the Rams gave up 110.8 rushing yards per game (12th).
  • On the other hand, the Rams averaged 126.6 rushing yards per game last season (7th in the league), while the 49ers gave up 107.8 rushing yards per game (11th).

Protecting the ball

  • Looking at their ability to force turnovers, the 49ers recorded 16 total takeaways last season (T23rd in the league), failing to perform to the same level as the Rams, who recorded 26 (5th).
  • On offense, the 49ers recorded 22 total giveaways last season (20th in the league), while the Rams took better care of the ball, recording 15 (T4th).

First to Score

  • The 49ers scored first in nine of their 19 games last season.
  • The Rams scored first in 11 of their 20 games last season.

Which team will score the first touchdown?

  • The 49ers recorded the first touchdown in 10 of their 19 games last season.
  • The Rams recorded the first touchdown in 12 of their 17 games last season.

First Scoring Play

    Play Frequency Odds
    San Francisco Touchdown8 / 19
    San Francisco Field Goal1 / 19
    San Francisco Safety0 / 19
    LA Rams Touchdown9 / 17
    LA Rams Field Goal2 / 17
    LA Rams Safety0 / 17

Which team will get a quick start?

  • The 49ers were the first to score 10 points in 12 of their 19 games last season.
  • The Rams were the first to score 10 points in 13 of their 17 games last season.

First Quarter Moneyline

  • The 49ers had a 10-5-4 first quarter W/L/T record last season, while the Rams held a record of 10-7-3.

Last Time They Met

The Rams recorded a 42-26 victory over the 49ers at Levi's Stadium when these teams last met in Week 10, 2025. The Rams have now won three straight at Levi's Stadium against the 49ers.